I am visiting Prague right now and I discovered UrbiRun!
I loved it. I am here for work, so not a lot of time for sightseeing, but the run allowed me to see some city highlights.
Navigation worked well, as well as the explanation about the sights
Good distance also, and not to many obstacles like street crossings where you have to wait
(via DM in instagram @maaikedoyer)

Running in Prague - Highlights
Prague, distance: 9.5km
In front of the Municipal House, close to Namesti Republiky
Like all urbirun routes, you can start wherever you like. Pay attention to the direction of the tour.
Running in Prague - Highlights and delights
In the heart of Europe, the westernmost of eastern european cities is fascinating with its intermingling of cultures. From the presence of the legendary alchemists of the 16th century, Prag, forever romantic, was in turn a royal town, then imperial city, provincial town under the communist régime, until becoming radiant and creative capital of a modern state.
Explore the cobbled streets of the Old Town, go up to the castle hill, jump from one bank to the other of the sublime Vltava, and enjoy the wonderful blend of modernity and history that this unique and charming city offers, along one of our favorite sighrunning tour (shhhht).
*Alternative route : the standard 9.5km can be shortened or extended depending on your will and fitness of the day. Just let's guide you...
Bonus
2 more options available : short tour 7.3km and long tour 11.5km (includes Letenska Park), and you can as well run this exclusive and unpublished tour, through Petrin Parc natural forests and Old Town.
Read what running in Prague is like, on the blog.
Find all Urbirun routes in GPX format in the Urbirun GPX boutique!